Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders

One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) metabolic pathological processes, particularly adipose tissue, oxidative stress, inflammation, diabetes cancer. HIF1A basic helix-loophelix PAS domain containing protein, considered master regulator cellular developmental hypoxia. HIF-1a regulates expression genes involved angiogenesis, glucose inflammation stress. In obesity, tissue leads increased HIF-1a, can lead chronic dysfunction. Another field that also cancer pathogenesis pathways, metastasis, potential therapeutic target metabolic/genetic diseases Direct indirect HIF-1 inhibitors have been identified, but only few entered clinical trials due their multiple side effects.